More: Apple Podcasts | ESPN App | RSS If you’re a fan of our podcasts, be sure to subscribe on Apple Podcasts and leave a rating/review. That helps spread the word to other listeners. And get in touch by email, on Twitter or in the comments. Tell us what you think, send us hot takes to discuss and tell us why we’re wrong. Welcome to this week’s episode of Hot Takedown, our podcast where the hot sports takes of the week meet the numbers that prove them right or tear them down. On this week’s show (Sept. 15, 2015), we discuss the allegations that the Patriots interfered with the Steelers’ communications in their Week 1 matchup. Then, Carl Bialik breaks down whether it’s time to start thinking of Novak Djokovic as the best men’s tennis player of all time — even though everyone seems to root for Roger Federer instead. And, can Yoenis Cespedes win National League MVP even though he’s only been in the National League for a few months? Plus, an update from FiveThirtyEight’s Walt Hickey on our crowdsourcing Madden challenge to win the Super Bowl using his avatar. And to close out the show, a Significant Digit on a turnaround for Kansas City’s women’s soccer team.Stream the episode by clicking the play button, or subscribe using one of the podcast clients we’ve linked to above. Below are links to some of what we discussed on the show:Want to win Madden with Walt Hickey as your quarterback? Here’s how to take part in our crowdsourcing project.ESPN’s list of injuries in the NFL.The Patriots’ home and road records in the Belichick era as compared to the rest of the league.When the Giants decided to pass on third down near the end of their Week 1 game against Dallas, they doubled the Cowboys’ win probability.Djokovic and Federer are vying to become the greatest of all time.Carl Bialik found that Roberta Vinci’s upset of Serena Williams was the biggest in modern women’s tennis.FanGraphs breaks down the argument for Yoenis Cespedes for MVP.The full archive of Baseline podcasts from Carl Bialik.Significant Digit: 4 — the number of teams that FC Kansas City of the National Women’s Soccer League leapfrogged to finish the regular season in third. FC Kansas City will face regular-season champion Seattle Reign FC in a repeat of last year’s National Women’s Soccer League final. Hot Takedown
Junior defensive lineman Joey Bosa put on his helmet during a March 26 practice at the Woody Hayes Athletic Center.Credit: Lantern file photoCHICAGO — A one-game suspension for a quartet of players may have been the first major setback to the 2015 Ohio State season, but members of the defending national champions aren’t letting it break their spirits.OSU announced Thursday that junior defensive lineman Joey Bosa, redshirt sophomore H-back Jalin Marshall, junior H-back Dontre Wilson and redshirt senior wide receiver Corey Smith had each been banned from the Buckeyes’ season opener on Sept. 7 at Virginia Tech for a violation of a Department of Athletics policy.While the suspensions were made public Thursday morning, OSU coach Urban Meyer said later that day during the 2015 Big Ten Media Days that it is an issue that he had been aware of for longer than that.“I kind of knew about this for a little bit,” Meyer said. “The athletic department has policies that we expect, and I 100 percent am fully supportive of it.”Meyer opted not to disclose the details of the violations, saying it was an “internal” team matter.Senior linebacker Joshua Perry said he was disappointed to see the punishments dished out, but he acknowledged there is a team code of taking responsibility for actions.“We’re disappointed because we value a high level of accountability,” Perry said. “But at the same time, you have to realize that guys do make mistakes; nobody is perfect, so as much as you want to eliminate those mistakes, you got to recognize them, you got to do something about them, and then you got to do something about it.”While each of the four suspended players are set to play major roles for the Buckeyes this season, Bosa’s absence against Virginia Tech — a team that handed OSU its only loss of the 2014 season — figures to be the most notable. Bosa was a unanimous 2014 Associated Press first-team All-America selection and finished as a finalist for three major national awards.However, Perry said he has faith in the depth and talent that the Buckeyes have to make up for the absence of the four.“If you go down our roster, and you see some of the other players we have that can step in, it’s not too worrisome,” Perry said.Missing a player who picked up 13.5 sacks last season in Bosa is never ideal for a defense, but Perry said the OSU defense has never been about the individuals.“We’re a no-name kind of defense,” he said. “What I mean by that is we want to take the individual identities away and we want to have a group identity.“We want to focus on that identity, the power of a total unit coming together. So when one guy goes down, it’s not even about the name anyway, you have to have another guy step up and know that with 11 guys doing their job, you can be successful.”The senior singled out players such as redshirt freshmen defensive linemen Sam Hubbard and Darius Slade, as well as sophomore defensive lineman Jalyn Holmes to pick up the defensive slack in the opener with Bosa out, and a pair of wide receivers in sophomore Curtis Samuel and junior Michael Thomas supporting the offense.Senior offensive lineman Taylor Decker was able to draw positives from the suspensions, citing a manufactured sense of urgency that can be valuable to a team.“I think it’s a huge opportunity for those guys who are going to step into those positions,” Decker said. “I think it might create a sense of urgency for the guys who are going to have to sit out that game because they’re probably going to be on scout team for the entirety of camp and those other guys are going to get the opportunity to take that spot and if they do a better job, they’re not going to get that spot back.”“So I think it’s going to create a sense of urgency all around, and I think it’s going to be beneficial, because if you break the rules you are going to punished no matter who you are. I don’t want to say I’m happy it happened, but I think there can be positives that come from it.”OSU — sans the four suspended players — is set to take the field for the season opener on Sept. 7. Kickoff is scheduled for 8 p.m in Blacksburg, Va.
The Polish striker is the hottest player in the Italian Lega Serie A having scored 14 goals in his last 10 competitive matchesPolish forward Krzysztof Piatek recently joined Genoa in the Italian Lega Serie A.The footballer has only played 7 matches, where he has scored 9 goals for his club.And there have been many rumors of him leaving Genoa soon, but there’s nothing official.“Many clubs have contacted us, but there has been no formal offer,” Piatek’s agent Szymon Pacanowski was echoed by Football Italia.“Many clubs have contacted us over the last few weeks, but I won’t name them.”“However, there has been no formal offer from any club, including Napoli,” he added.Serie A Betting: Match-day 3 Stuart Heath – September 14, 2019 Considering there is a number of perfect starts so early in the Serie A season, as well as a few surprisingly not-so perfect ones….“His value has certainly risen over the three months in Serie A, but right now we are happy to remain at Genoa.”📋 – Straight off the training ground!Take a look at how Krzysztof Piatek gave Poland the lead against Portugal…Watch Poland v Portugal live on Sky Sports Football Red Button or watch in-game clips and highlights here: https://t.co/orKC8PgnPR pic.twitter.com/vlh1GWtWlC— Sky Sports Football (@SkyFootball) October 11, 2018
(Left) The different molecular structures of the two natural base pairs (black) and the artificial base pair (red and blue) cause the base pairs to absorb light at different wavelengths, as shown at right. The average solar spectrum reaching the Earth’s surface is shown in orange, and the emission spectrum from standard fluorescent lighting is in yellow. Credit: Pollum et al. ©2016 American Chemical Society To investigate how this light absorption difference may affect living cells, the researchers in the new study performed an experiment with living cancer cells from human skin (epidermoid carcinoma cells). When exposed to a low dose of near-visible light, cells that had not been treated with the artificial nucleoside d5SICS exhibited no change in cell survival. Cells that had been treated with the artificial nucleoside, but not exposed to near-visible light, were similarly unaffected. But cells containing the artificial nucleoside that were briefly exposed to near-visible light exhibited a substantial decrease in cell proliferation, indicating that the artificial nucleoside had photosensitized these cells to near-visible light, resulting in photochemical damage. (Left) When exposed to low doses of near-visible light, living skin cancer cells that contain d5SICS exhibit a large decrease in cell proliferation compared to those not exposed to the light. (Right) Cells with d5SICS exposed to near-visible light show high levels of reactive oxygen species (ROS), as seen by the fluorescence of the ROS dye, compared to cells with d5SICS that were not exposed to the light. Credit: Pollum et al. ©2016 American Chemical Society Explore further Citation: Unintended consequences of creating the world’s first semisynthetic organism (2016, September 12) retrieved 18 August 2019 from https://phys.org/news/2016-09-unintended-consequences-world-semisynthetic.html © 2016 Phys.org Based on further investigation, the researchers think that one of the most probable mechanisms of the light-induced damage is that light exposure produces reactive oxygen species (ROS) inside the cells. High levels of ROS are known to cause cell damage, and the living cells containing the artificial nucleoside exhibited much higher levels of ROS upon exposure to near-visible light than untreated cells did.Overall, the results illustrate the complexities involved in the ways that making even a small modification to an organism’s genetic code may have far-reaching and unforeseen consequences for the entire organism.The upside, however, is that some of the unforeseen consequences may have benefits if used in a controlled way. For instance, the researchers are currently investigating how the phototoxicity of the artificial nuceloside could be used as a method to treat cancer.”The significant phototoxic activity of d5SICS in epidermoid carcinoma cells has the potential to open new opportunities for its use in topical photodynamic therapy applications, as our group and others have recently proposed for several nucleobase analogues,” Crespo-Hernández said.The authors acknowledge funding from the National Science Foundation CAREER Program (Grant CHE-1255084 and CHE-1539808). Chemists create mimic of key vision protein More information: Marvin Pollum et al. “Unintended Consequences of Expanding the Genetic Alphabet.” Journal of the American Chemical Society. DOI: 10.1021/jacs.6b06822 Journal information: Journal of the American Chemical Society (Phys.org)—In 2014, the incorporation of two artificial letters of genetic code into the DNA of Escherichia coli gave the bacteria the distinction of becoming the world’s first stable semisynthetic organism. The modification was intended to illustrate the possibility of enabling organisms to incorporate and replicate an artificial base pair for the future biosynthesis of novel proteins. But now in a new study, scientists have discovered that the artificial base pair has an unintended consequence on living cells: phototoxicity. The new results show that the artificial base pair makes living cells more susceptible to damage from low doses of sunlight and standard fluorescent light bulbs, leading to a significant decrease in cell survival and growth.The study, titled “Unintended Consequences of Expanding the Genetic Alphabet,” is published in a recent issue of the Journal of the American Chemical Society by a team of researchers led by Carlos E. Crespo-Hernández from Case Western Reserve University, along with coauthors from Case Western and Columbia University.”There is currently an ongoing quest to genetically modify living cells and organisms with different purposes,” Crespo-Hernández told Phys.org. “Our work clearly cautions scientists that care must be exercised when efforts are made to expand the genetic alphabet, especially if the synthetic organisms may be exposed to light—a fact that has been hitherto overlooked.”The artificial base pair consists of two nucleosides (which are nucleotides without a phosphate group) called d5SICS and dNaM. These artificial nucleosides have different chemical structures than the natural nucleosides, which are those made of the adenine, guanine, thymine, and cytosine nucleobases. Due to their different chemical structures, the artificial and natural nucleosides absorb light at different wavelengths. The artificial nucleosides strongly absorb light with wavelengths in the near-visible range, or just under 400 nm. In contrast, natural nucleosides absorb light most strongly at higher energies, those with wavelengths less than 300 nm. Since everyday lighting, such as the sunlight that reaches Earth’s surface and fluorescent light bulbs, contains much more light in the near-visible range than in the higher-energy ultraviolet range, we receive significantly greater exposure to light with near-visible wavelengths. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
26Mar Allor plan allowing DNR firefighters to provide mutual aid becomes law Categories: Allor News Firefighters with the Michigan Department of Natural Resources will now be able to assist with search and rescue operations following natural disasters in other states – something that was not allowed prior to legislation introduced by state Rep. Sue Allor, which was signed into law last week.Allor, of Wolverine, said DNR firefighters were previously able to respond to forest fires in other states, but not other emergencies such as floods, hurricanes and other disasters.“Every year, and often multiple times a year, requests are made asking our state to help during emergencies,” Allor said. “Last year, the DNR deployed more than 150 employees to fight out-of-state forest fires but state law prevented the DNR from assisting people in need following other events, like Hurricane Harvey. This reform allows us to step up and help our neighbors in need.”Allor said Michigan is reimbursed for all costs incurred when responding to emergencies in other states, and the DNR is not required to send assistance when a request is made.“The DNR will weigh each request against in-state work, with the safety and security of Michigan residents taking top priority,” Allor said. “But if the time is right and we can provide assistance, Michigan firefighters will gain valuable experience and learn skills they can put to use here at home.”Allor said Alpena Fire Chief Bill Forbush played a key role in the legislative process.“I want to thank Chief Forbush, first for bringing the issue to my attention and also for testifying in support of the bill during committee,” Allor said. “He provided a tremendous amount of helpful insight and knowledge.”Allor’s legislation, House Bill 5198, is now Public Act 80 of 2018.###